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Catalog Number:
14061
CAS Number:
487027-89-4
Nα-Fmoc-D-2,3-diaminopropionic acid hydrochloride
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Dap-OH·HCl
Documents
$60.40 /250MG
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Product Information

Na-Fmoc-D-2,3-diaminopropionic acid hydrochloride is a versatile building block in peptide synthesis, particularly valued for its role in the development of peptide-based therapeutics and research applications. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which provides stability during synthesis and facilitates the selective deprotection of the amine group. Its unique structure allows for the introduction of D-amino acids into peptides, enhancing their biological activity and stability. Researchers utilize Na-Fmoc-D-2,3-diaminopropionic acid hydrochloride in various applications, including drug design, protein engineering, and the synthesis of cyclic peptides, which are known for their high affinity and specificity in biological interactions.

The compound's ability to improve the pharmacokinetic properties of peptides makes it an essential tool for medicinal chemists and biochemists. Its compatibility with standard coupling reagents and protocols streamlines the synthesis process, allowing for efficient production of complex peptide sequences. With its proven efficacy in enhancing peptide stability and activity, Na-Fmoc-D-2,3-diaminopropionic acid hydrochloride stands out as a critical component in advancing peptide research and development.

Synonyms
Fmoc-D-Dap-OH·HCl
CAS Number
487027-89-4
Purity
≥ 98% (HPLC)
Molecular Formula
C18H18N2O4·HCl
Molecular Weight
362.84
MDL Number
MFCD03788624
PubChem ID
75305800
Melting Point
176 - 187 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = 20 ± 10 °
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Dap-OH·HCl
CAS Number
487027-89-4
Purity
≥ 98% (HPLC)
Molecular Formula
C18H18N2O4·HCl
Molecular Weight
362.84
MDL Number
MFCD03788624
PubChem ID
75305800
Melting Point
176 - 187 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = 20 ± 10 °
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-D-2,3-diaminopropionic acid hydrochloride is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for selective reactions and improving yield and purity.
  • Drug Development: It plays a crucial role in the design of peptide-based pharmaceuticals, aiding in the development of targeted therapies for various diseases.
  • Bioconjugation: The chemical is used in bioconjugation processes, facilitating the attachment of biomolecules to surfaces or other molecules, which is essential in diagnostics and therapeutics.
  • Research in Neuroscience: It is applied in studies related to neuropeptides, helping researchers understand their role in brain function and potential treatments for neurological disorders.
  • Custom Synthesis: Laboratories utilize this compound for custom synthesis of specific amino acid derivatives, catering to specialized research needs in various fields.

Citations