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Catalog Number:
14841
CAS Number:
170643-02-4
Fmoc-O-tert-butyl-D-allo-threonine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-allo-Thr(tBu)-OH
Documents
$168.35 /100MG
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Product Information

Fmoc-O-tert-butyl-D-allo-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its tert-butyl group enhances solubility and stability, making it an ideal choice for researchers looking to streamline their synthesis processes. The unique structure of Fmoc-O-tert-butyl-D-allo-threonine allows for efficient coupling reactions, facilitating the creation of complex peptide sequences with high purity and yield.

In practical applications, this compound is particularly valuable in the fields of medicinal chemistry and biochemistry, where it serves as a building block for the development of therapeutic peptides and proteins. Its ability to provide stability and protection during synthesis makes it a preferred choice among professionals engaged in peptide research and development. By incorporating Fmoc-O-tert-butyl-D-allo-threonine into their workflows, researchers can enhance the efficiency and effectiveness of their peptide synthesis, ultimately leading to innovative solutions in drug discovery and development.

Synonyms
Fmoc-D-allo-Thr(tBu)-OH
CAS Number
170643-02-4
Purity
≥ 99% (HPLC)
Molecular Formula
C23H27NO5
Molecular Weight
397.47
MDL Number
MFCD00077074
PubChem ID
3085672
Melting Point
81-90 ºC
Appearance
White powder
Optical Rotation
[a]D20 = -21.6 ± 2º (C=1 in EtOAc)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-allo-Thr(tBu)-OH
CAS Number
170643-02-4
Purity
≥ 99% (HPLC)
Molecular Formula
C23H27NO5
Molecular Weight
397.47
MDL Number
MFCD00077074
PubChem ID
3085672
Melting Point
81-90 ºC
Appearance
White powder
Optical Rotation
[a]D20 = -21.6 ± 2º (C=1 in EtOAc)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-D-allo-threonine is widely utilized in research focused on

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity and yield.
  • Drug Development: Its application in drug design helps in the development of therapeutic peptides, which can target specific biological pathways, enhancing efficacy and reducing side effects compared to traditional small-molecule drugs.
  • Bioconjugation: The chemical is used for bioconjugation processes, enabling the attachment of peptides to various biomolecules, which is essential for creating targeted drug delivery systems and diagnostic agents.
  • Research in Protein Engineering: Researchers utilize this compound to modify proteins, facilitating the study of protein interactions and functions, which is crucial for understanding disease mechanisms and developing new treatments.
  • Analytical Chemistry: It serves as a useful reagent in analytical techniques, such as mass spectrometry, to improve the detection and characterization of peptides, providing valuable insights in proteomics studies.

Citations