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Catalog Number:
15113
CAS Number:
478183-59-4
Fmoc-3-chloro-D-tyrosine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-m-chloro-D-Tyr-OH
Documents
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Product Information

Fmoc-3-chloro-D-tyrosine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. Its structural characteristics, including the presence of a chloro substituent on the aromatic ring, enhance its reactivity and allow for the incorporation of this amino acid into complex peptide sequences, making it invaluable for researchers in medicinal chemistry and biochemistry.

In practical applications, Fmoc-3-chloro-D-tyrosine is particularly beneficial for the synthesis of bioactive peptides and pharmaceuticals, where precise control over amino acid incorporation is crucial. Its ability to provide stability and protection during synthesis, coupled with its compatibility with various coupling reagents, positions it as a preferred choice among professionals in the field. Researchers can leverage this compound to explore new therapeutic avenues, including the development of targeted drug delivery systems and the design of peptide-based therapeutics.

Synonyms
Fmoc-m-chloro-D-Tyr-OH
CAS Number
478183-59-4
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20ClNO5
Molecular Weight
430.0
MDL Number
MFCD03840399
PubChem ID
53421061
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 20 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-m-chloro-D-Tyr-OH
CAS Number
478183-59-4
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20ClNO5
Molecular Weight
430.0
MDL Number
MFCD03840399
PubChem ID
53421061
Appearance
White to off-white powder
Optical Rotation
[a]D20 = 20 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-3-chloro-D-tyrosine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of chlorinated tyrosine residues.
  • Drug Development: It is used in the development of novel pharmaceuticals, especially those targeting specific biological pathways, due to its unique structural properties that can enhance drug efficacy.
  • Bioconjugation: The compound is valuable in bioconjugation processes, where it can be used to attach biomolecules to surfaces or other molecules, facilitating the creation of targeted drug delivery systems.
  • Research in Neuroscience: Its application in studying neurotransmitter systems is significant, as chlorinated tyrosine derivatives can mimic natural neurotransmitters, aiding in the understanding of receptor interactions.
  • Fluorescent Labeling: Fmoc-3-chloro-D-tyrosine can be employed in fluorescent labeling techniques, enhancing the visualization of proteins in various biological assays, which is crucial for many research applications.

Citations