Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
16199
CAS Number:
374899-60-2
Nα-Fmoc-6-hydroxynorleucine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Nle(6-OH)-OH
Documents
$121.28 /250MG
Pack Size Availability Price
Request Bulk Quote
Product Information

Na-Fmoc-6-hydroxynorleucine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure allows for enhanced stability and solubility, making it an ideal choice for researchers focused on developing complex peptide sequences. The hydroxyl group at the 6-position further enhances its reactivity, facilitating the incorporation of this amino acid into various peptide chains.

In practical applications, Na-Fmoc-6-hydroxynorleucine is particularly valuable in the pharmaceutical industry for the design of bioactive peptides that can serve as therapeutic agents. Its ability to improve the pharmacological properties of peptides, such as stability and bioavailability, makes it a preferred choice among researchers. Additionally, its use in combinatorial chemistry and high-throughput screening can accelerate the discovery of new drugs, providing significant advantages over similar compounds. This compound is essential for those looking to innovate in peptide-based therapies and enhance their research outcomes.

Synonyms
Fmoc-L-Nle(6-OH)-OH
CAS Number
374899-60-2
Purity
≥ 98% (HPLC)
Molecular Formula
C21H23NO5
Molecular Weight
369.4
MDL Number
MFCD04973185
PubChem ID
69109888
Melting Point
96 - 119 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = -4 ± 1 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Nle(6-OH)-OH
CAS Number
374899-60-2
Purity
≥ 98% (HPLC)
Molecular Formula
C21H23NO5
Molecular Weight
369.4
MDL Number
MFCD04973185
PubChem ID
69109888
Melting Point
96 - 119 °C
Appearance
White crystalline powder
Optical Rotation
[a]D20 = -4 ± 1 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-6-hydroxynorleucine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and functional peptide structures.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing new drugs, especially those targeting specific biological pathways, enhancing the efficacy of therapeutic agents.
  • Bioconjugation: The chemical is used in bioconjugation processes, where it helps attach biomolecules to other molecules, facilitating the development of targeted drug delivery systems.
  • Research in Protein Engineering: Researchers utilize it in studies aimed at modifying proteins to improve their stability and activity, which is crucial for developing better biopharmaceuticals.
  • Analytical Chemistry: It is employed in analytical methods to study protein interactions and dynamics, providing insights that are vital for understanding biological processes.

Citations