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Catalog Number:
16866
CAS Number:
193693-61-7
Fmoc-D-β-homoproline
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-D-β-HomoPro-OH, (R-2-(1-Fmoc-2-pyrrolidinyl)acetic acid
Documents
$113.87 /100MG
Pack Size Availability Price
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Product Information

Fmoc-D-b-homoproline is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amines during the synthesis of complex peptides. Its unique structure allows for the incorporation of D-homoproline into peptides, enhancing their stability and bioactivity. Researchers and industry professionals appreciate Fmoc-D-b-homoproline for its ability to facilitate the formation of cyclic peptides and its role in the development of peptide-based therapeutics, particularly in the fields of oncology and neurology.

The compound's properties make it an excellent choice for solid-phase peptide synthesis, where its Fmoc group can be easily removed under mild conditions, allowing for efficient coupling reactions. Additionally, Fmoc-D-b-homoproline has shown promise in enhancing the pharmacological profiles of peptides, making it a valuable tool for medicinal chemists. Its application in the synthesis of bioactive compounds underscores its significance in advancing drug discovery and development.

Synonyms
Fmoc-D-β-HomoPro-OH, (R-2-(1-Fmoc-2-pyrrolidinyl)acetic acid
CAS Number
193693-61-7
Purity
≥ 99% (HPLC)
Molecular Formula
C21H21NO4
Molecular Weight
351.4
MDL Number
MFCD06202403
PubChem ID
4384954
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +42 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-β-HomoPro-OH, (R-2-(1-Fmoc-2-pyrrolidinyl)acetic acid
CAS Number
193693-61-7
Purity
≥ 99% (HPLC)
Molecular Formula
C21H21NO4
Molecular Weight
351.4
MDL Number
MFCD06202403
PubChem ID
4384954
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +42 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-b-homoproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as an important building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: Researchers leverage Fmoc-D-b-homoproline in the design of peptide-based drugs, especially in the development of therapeutics targeting specific biological pathways, enhancing efficacy and reducing side effects.
  • Protein Engineering: It is used to modify proteins and enzymes, enabling scientists to study structure-function relationships and improve the stability and activity of proteins in various applications.
  • Bioconjugation: This chemical facilitates the attachment of biomolecules to surfaces or other molecules, which is crucial in creating targeted drug delivery systems and diagnostic tools.
  • Research in Neuroscience: Fmoc-D-b-homoproline is explored in studies related to neuropeptides, contributing to the understanding of neural signaling and potential treatments for neurological disorders.

Citations