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Catalog Number:
24490
CAS Number:
18156-74-6
1-(Trimethylsilyl)imidazole
Purity:
≥ 98% (GC)
Synonym(s):
N-Trimethylsilylimidazole
Documents
$22.03 /25G
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Product Information

1-(Trimethylsilyl)imidazole is a versatile organosilicon compound that serves as an essential reagent in various chemical syntheses. Its unique trimethylsilyl group enhances the stability and reactivity of the imidazole moiety, making it an invaluable tool in organic synthesis, particularly in the field of medicinal chemistry. This compound is widely utilized as a protecting group for amines and alcohols, facilitating the selective functionalization of complex molecules. Additionally, it plays a crucial role in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals, where its ability to stabilize reactive intermediates is highly beneficial.

Researchers and industry professionals appreciate 1-(Trimethylsilyl)imidazole for its efficiency in facilitating reactions such as nucleophilic substitutions and coupling reactions. Its compatibility with various solvents and mild reaction conditions further enhance its appeal, allowing for streamlined processes in laboratory and industrial settings. With its proven track record in enhancing reaction yields and selectivity, this compound stands out as a reliable choice for those seeking to optimize their synthetic pathways.

Synonyms
N-Trimethylsilylimidazole
CAS Number
18156-74-6
Purity
≥ 98% (GC)
Molecular Formula
C6H12N2Si
Molecular Weight
140.26
MDL Number
MFCD00005280
PubChem ID
28925
Density
0.956 g/mL at 25 °C
Appearance
Light yellow transparent liquid
Conditions
Store at 0-8 °C
General Information
Synonyms
N-Trimethylsilylimidazole
CAS Number
18156-74-6
Purity
≥ 98% (GC)
Molecular Formula
C6H12N2Si
Molecular Weight
140.26
MDL Number
MFCD00005280
PubChem ID
28925
Density
0.956 g/mL at 25 °C
Appearance
Light yellow transparent liquid
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

1-(Trimethylsilyl)imidazole is widely utilized in research focused on:

  • Organic Synthesis: This compound acts as a versatile reagent in organic chemistry, facilitating the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
  • Catalysis: It serves as a catalyst in numerous reactions, enhancing reaction rates and improving yields, which is particularly beneficial in the production of fine chemicals.
  • Silicon-based Materials: The compound is used in the development of silicon-containing polymers and materials, which are essential in electronics and coatings industries.
  • Analytical Chemistry: It is employed in sample preparation techniques, such as derivatization for gas chromatography, allowing for improved detection and analysis of compounds.
  • Biochemistry: This chemical is useful in modifying biomolecules, aiding in the study of enzyme activity and protein interactions, thus supporting advancements in drug discovery.

Citations