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Catalog Number:
31972
Fmoc-O-tert-butyl-D-β-homothreonine
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-D-β-HomoThr(tBu)-OH, (3S,4S-4-tert-Butoxy-3-(Fmoc-amino)pentanoic acid
Documents
$79.22 /100MG
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Product Information

Fmoc-O-tert-butyl-D-b-homothreonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which facilitates the selective coupling of amino acids during solid-phase peptide synthesis. Its tert-butyl protective group enhances solubility and stability, making it an ideal choice for researchers focused on synthesizing complex peptides with high purity and yield.

In the pharmaceutical industry, Fmoc-O-tert-butyl-D-b-homothreonine plays a crucial role in the development of therapeutic peptides, particularly those targeting specific biological pathways. Its unique structure allows for the incorporation of homothreonine into peptide sequences, which can enhance biological activity and specificity. Researchers appreciate its compatibility with various coupling reagents and its ability to streamline the synthesis process, ultimately leading to more efficient and cost-effective production of peptide-based drugs.

Synonyms
Fmoc-D-β-HomoThr(tBu)-OH, (3S,4S-4-tert-Butoxy-3-(Fmoc-amino)pentanoic acid
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H29NO5
Molecular Weight
411.5
MDL Number
MFCD22371794
Appearance
White solid
Optical Rotation
[a]20D = -17 to -19 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-β-HomoThr(tBu)-OH, (3S,4S-4-tert-Butoxy-3-(Fmoc-amino)pentanoic acid
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C24H29NO5
Molecular Weight
411.5
MDL Number
MFCD22371794
Appearance
White solid
Optical Rotation
[a]20D = -17 to -19 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-D-b-homothreonine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex structures with specific functionalities.
  • Drug Development: Its unique properties make it valuable in the pharmaceutical industry for developing new drugs, particularly those targeting specific biological pathways.
  • Bioconjugation: The compound is used in bioconjugation processes, enabling the attachment of biomolecules to surfaces or other molecules, which is crucial in diagnostics and therapeutic applications.
  • Research in Protein Engineering: It plays a significant role in protein engineering, helping scientists design proteins with enhanced stability and activity for various applications.
  • Academic Research: Many academic institutions utilize this compound in studies related to molecular biology and biochemistry, facilitating advancements in understanding cellular mechanisms.

Citations