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Catalog Number:
37765
CAS Number:
81129-83-1
Cilastatin sodium salt
Purity:
≥ 98% (HPLC)
Synonym(s):
Monosodium (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoate, (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoic acid monosodium salt
Temperature Sensitive
Documents
$188.28 /50MG
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Product Information

Cilastatin sodium salt is a potent inhibitor of the enzyme dehydropeptidase I, primarily used in conjunction with certain antibiotics to enhance their efficacy. By preventing the breakdown of beta-lactam antibiotics in the kidneys, Cilastatin sodium salt significantly increases their bioavailability, making it an essential component in treating bacterial infections. This compound is particularly valuable in clinical settings where it is paired with drugs like imipenem to combat resistant strains of bacteria, thus expanding treatment options for healthcare professionals.

In addition to its clinical applications, Cilastatin sodium salt is also of interest in pharmaceutical research, where its mechanism of action can be studied to develop new therapeutic strategies. Its unique ability to protect antibiotics from enzymatic degradation offers a significant advantage over similar compounds, ensuring that patients receive maximum therapeutic benefit. Researchers and industry professionals can leverage Cilastatin sodium salt's properties to innovate and improve treatment protocols, ultimately enhancing patient outcomes.

Synonyms
Monosodium (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoate, (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoic acid monosodium salt
CAS Number
81129-83-1
Purity
≥ 98% (HPLC)
Molecular Formula
C16H25N2NaO5S
Molecular Weight
380.43
MDL Number
MFCD08459332
PubChem ID
53395235
Appearance
White to almost white powder to crystal
Conditions
Store at < 0 °C
General Information
Synonyms
Monosodium (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoate, (R)-2-Amino-3-[[(Z)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-en-1-yl]thio]propanoic acid monosodium salt
CAS Number
81129-83-1
Purity
≥ 98% (HPLC)
Molecular Formula
C16H25N2NaO5S
Molecular Weight
380.43
MDL Number
MFCD08459332
PubChem ID
53395235
Appearance
White to almost white powder to crystal
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Cilastatin sodium salt is widely utilized in research focused on:

  • Pharmaceutical Development: It is primarily used to enhance the effectiveness of certain antibiotics by inhibiting renal dehydropeptidase, preventing the breakdown of drugs like imipenem. This application is crucial in developing effective treatments for serious infections.
  • Combination Therapy: Cilastatin is often combined with beta-lactam antibiotics in clinical settings, improving therapeutic outcomes for patients with severe bacterial infections, particularly in hospital environments.
  • Research in Pharmacokinetics: Researchers use cilastatin to study drug interactions and metabolism, providing insights into how drugs are processed in the body, which is essential for developing new medications.
  • Veterinary Medicine: Its application extends to veterinary practices, where it is used to treat infections in animals, ensuring that they receive effective antibiotic therapy without adverse effects.
  • Clinical Trials: Cilastatin is involved in various clinical trials aimed at discovering new therapeutic uses and improving existing antibiotic treatments, making it a valuable compound in advancing medical research.

Citations