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Catalog Number:
37803
CAS Number:
57808-66-9
Domperidone
Purity:
≥ 98% (Assay by titration, HPLC)
Synonym(s):
5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one
Documents
$208.31 /200MG
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Product Information

Domperidone is a widely recognized antiemetic agent, primarily used to alleviate nausea and vomiting associated with various medical conditions. This compound acts as a dopamine receptor antagonist, effectively blocking dopamine receptors in the gastrointestinal tract and the chemoreceptor trigger zone of the brain. Its unique ability to enhance gastric motility makes it particularly valuable in treating conditions such as gastroparesis and in managing side effects from certain medications, especially in patients undergoing chemotherapy.

In the pharmaceutical industry, Domperidone is often utilized in formulations aimed at improving digestive health and enhancing the efficacy of other therapeutic agents. Its favorable safety profile and effectiveness in reducing symptoms of nausea have made it a preferred choice among healthcare professionals. Additionally, ongoing research into its potential applications in treating other gastrointestinal disorders continues to highlight its versatility and importance in clinical settings.

Synonyms
5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one
CAS Number
57808-66-9
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C22H24ClN5O2
Molecular Weight
425.92
MDL Number
MFCD00069256
PubChem ID
3151
Melting Point
243 °C (dec.)
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one
CAS Number
57808-66-9
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C22H24ClN5O2
Molecular Weight
425.92
MDL Number
MFCD00069256
PubChem ID
3151
Melting Point
243 °C (dec.)
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Domperidone is widely utilized in research focused on:

  • Gastrointestinal Disorders: It is primarily used to treat nausea and vomiting, especially in patients undergoing chemotherapy or those with gastrointestinal disorders, providing relief and improving quality of life.
  • Parkinson's Disease Management: Domperidone is effective in alleviating gastrointestinal side effects associated with Parkinson's disease treatments, helping patients maintain better digestive health while managing their condition.
  • Research in Drug Formulation: In pharmaceutical development, it serves as a model compound for studying drug absorption and bioavailability, aiding researchers in formulating more effective medications.
  • Veterinary Medicine: It is also applied in veterinary practices to treat nausea in animals, showcasing its versatility beyond human medicine.
  • Clinical Trials: Domperidone is often included in clinical studies to evaluate its efficacy and safety in various patient populations, contributing valuable data to the medical community.

Citations