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Catalog Number:
37816
CAS Number:
23651-95-8
Droxidopa
Purity:
≥ 98% (Assay by titration, HPLC)
Synonym(s):
(2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid, L-threo-3,4-dihydroxyphenylserine
Documents
$186.98 /50MG
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Product Information

Droxidopa is a potent compound recognized for its role as a synthetic precursor to norepinephrine, making it invaluable in the treatment of neurogenic orthostatic hypotension. This condition, characterized by a significant drop in blood pressure upon standing, can severely impact the quality of life for patients. Droxidopa works by converting to norepinephrine in the body, thereby enhancing vascular tone and improving blood pressure regulation. Its unique ability to cross the blood-brain barrier allows for effective central nervous system action, making it a preferred choice in clinical settings for managing symptoms associated with autonomic dysfunction.

In addition to its primary use in treating orthostatic hypotension, Droxidopa has shown promise in various research applications, including studies on neurodegenerative diseases and conditions affecting the autonomic nervous system. Its favorable safety profile and efficacy make it an essential compound for researchers and healthcare professionals looking to explore innovative therapeutic avenues. With its targeted action and significant clinical benefits, Droxidopa stands out as a critical agent in both therapeutic and research contexts.

Synonyms
(2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid, L-threo-3,4-dihydroxyphenylserine
CAS Number
23651-95-8
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C9H11NO5
Molecular Weight
213.19
MDL Number
MFCD00799030
PubChem ID
3171
Melting Point
225 °C (dec.)
Appearance
White to light yellow powder to crystal
Optical Rotation
[a]20D = -38 to -43 ° (C=0.5 in 0.1 mol/L HCl) (after drying)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid, L-threo-3,4-dihydroxyphenylserine
CAS Number
23651-95-8
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C9H11NO5
Molecular Weight
213.19
MDL Number
MFCD00799030
PubChem ID
3171
Melting Point
225 °C (dec.)
Appearance
White to light yellow powder to crystal
Optical Rotation
[a]20D = -38 to -43 ° (C=0.5 in 0.1 mol/L HCl) (after drying)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Droxidopa is widely utilized in research focused on:

  • Treatment of Orthostatic Hypotension: This compound is primarily used to manage symptoms of low blood pressure, particularly in patients with conditions like Parkinson's disease. It helps improve blood flow and reduce dizziness upon standing.
  • Neurodegenerative Disease Research: Droxidopa is valuable in studying neurodegenerative diseases, as it can enhance norepinephrine levels in the brain, providing insights into potential therapies for conditions such as multiple system atrophy.
  • Cardiovascular Studies: Researchers utilize this compound to explore its effects on cardiovascular health, particularly in understanding blood pressure regulation and the body's response to stress.
  • Pharmaceutical Development: Droxidopa serves as a model compound in the development of new medications aimed at treating similar conditions, allowing scientists to evaluate efficacy and safety profiles.
  • Clinical Trials: It plays a crucial role in clinical trials aimed at assessing new treatment protocols for patients suffering from autonomic dysfunction, providing a benchmark for comparing new therapies.

Citations