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Catalog Number:
38464
CAS Number:
908846-88-8
Fmoc-5-fluoro-L-tryptophan
Purity:
≥ 99.9% (Chiral HPLC)
Synonym(s):
Fmoc-L-Trp(5-F)-OH
Documents
$80.00 /100MG
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Product Information

Fmoc-5-fluoro-L-tryptophan is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique fluorine substitution enhances the compound's properties, making it an excellent choice for researchers focused on developing novel therapeutics and studying protein interactions. The incorporation of Fmoc-5-fluoro-L-tryptophan into peptide sequences can improve the stability and bioactivity of the resulting compounds, offering significant advantages in pharmaceutical applications.

In addition to its role in peptide synthesis, Fmoc-5-fluoro-L-tryptophan is also valuable in the study of tryptophan metabolism and its implications in various biological processes. Its distinct characteristics allow for the exploration of tryptophan's role in neurotransmitter synthesis and the modulation of mood and behavior. Researchers can leverage this compound to gain insights into complex biochemical pathways, making it a crucial tool in both academic and industrial settings.

Synonyms
Fmoc-L-Trp(5-F)-OH
CAS Number
908846-88-8
Purity
≥ 99.9% (Chiral HPLC)
Molecular Formula
C26H21FN2O4
Molecular Weight
444.45
MDL Number
MFCD24842544
PubChem ID
22309438
Melting Point
161 - 178 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -20.5 ± 2 ° (C = 1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Trp(5-F)-OH
CAS Number
908846-88-8
Purity
≥ 99.9% (Chiral HPLC)
Molecular Formula
C26H21FN2O4
Molecular Weight
444.45
MDL Number
MFCD24842544
PubChem ID
22309438
Melting Point
161 - 178 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -20.5 ± 2 ° (C = 1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-5-fluoro-L-tryptophan is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, where its protective group facilitates the sequential addition of amino acids.
  • Drug Development: Its unique fluorinated structure can enhance the pharmacological properties of peptides, making it valuable in the design of novel therapeutics targeting various diseases.
  • Bioconjugation: The compound can be used in bioconjugation processes, allowing researchers to attach peptides to other biomolecules or surfaces, which is essential in creating targeted drug delivery systems.
  • Fluorescent Labeling: The fluorine atom provides potential for fluorescent labeling, enabling visualization in biological assays and enhancing the study of protein interactions.
  • Research in Neuroscience: Its structural similarity to neurotransmitters makes it useful in studies related to serotonin receptors, helping researchers understand neurological pathways and disorders.

Citations