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Catalog Number:
45330
CAS Number:
372-31-6
Ethyl 4,4,4-trifluoroacetoacetate
Purity:
≥ 98% (GC)
Synonym(s):
4,4,4-Trifluoroacetoacetic acid ethyl ester
Hazmat
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$93.90 /25G
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Product Information

Ethyl 4,4,4-trifluoroacetoacetate is a versatile compound recognized for its unique trifluoromethyl group, which enhances its reactivity and solubility in various organic solvents. This compound is particularly valuable in the synthesis of fluorinated pharmaceuticals and agrochemicals, where the trifluoromethyl group can significantly influence biological activity and metabolic stability. Its ability to act as a building block in the preparation of complex molecules makes it an essential reagent in organic synthesis, especially in the development of novel therapeutic agents.

Researchers and industry professionals appreciate Ethyl 4,4,4-trifluoroacetoacetate for its role in the production of fluorinated intermediates, which are crucial in medicinal chemistry. Its unique properties allow for the efficient formation of carbon-carbon bonds, facilitating the creation of diverse chemical structures. This compound is also utilized in the synthesis of various fluorinated compounds, enhancing the efficacy and specificity of end products. With its broad applicability and significant advantages over non-fluorinated analogs, Ethyl 4,4,4-trifluoroacetoacetate stands out as a key player in modern chemical synthesis.

Synonyms
4,4,4-Trifluoroacetoacetic acid ethyl ester
CAS Number
372-31-6
Purity
≥ 98% (GC)
Molecular Formula
C6H7F3O3
Molecular Weight
184.11
MDL Number
MFCD00000424
PubChem ID
67793
Melting Point
-30 °C
Density
1.25
Appearance
Colorless to almost colorless clear liquid
Boiling Point
132 °C
Refractive Index
n20D 1.38
Conditions
Store at 2 - 8 °C
General Information
Synonyms
4,4,4-Trifluoroacetoacetic acid ethyl ester
CAS Number
372-31-6
Purity
≥ 98% (GC)
Molecular Formula
C6H7F3O3
Molecular Weight
184.11
MDL Number
MFCD00000424
PubChem ID
67793
Melting Point
-30 °C
Density
1.25
Appearance
Colorless to almost colorless clear liquid
Boiling Point
132 °C
Refractive Index
n20D 1.38
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Ethyl 4,4,4-trifluoroacetoacetate is widely utilized in research focused on:

  • Synthesis of Fluorinated Compounds: This chemical serves as a key building block in the synthesis of various fluorinated organic compounds, which are valuable in pharmaceuticals and agrochemicals due to their unique properties.
  • Medicinal Chemistry: It plays a crucial role in drug development, particularly in creating compounds with enhanced biological activity and stability, making it a favorite among medicinal chemists.
  • Material Science: The compound is used in the formulation of advanced materials, including coatings and polymers, that require specific thermal and chemical resistance.
  • Research in Catalysis: It is employed in studies related to catalytic processes, helping researchers understand and develop more efficient catalytic systems for organic transformations.
  • Analytical Chemistry: Ethyl 4,4,4-trifluoroacetoacetate is utilized in analytical methods for detecting and quantifying fluorinated compounds, aiding in environmental monitoring and quality control.

Citations